Research Library

Welcome to The AERD Research Library

Browse this collection of publications and research related to AERD (Samter's Triad). Be sure to check for updates - we add new materials frequently.

General Info & News

The Burden of NSAID Exacerbated Respiratory Disease from the Patient’s Perspective – A Qualitative Analysis of Posts from the Samter’s Society

Aspirin-Exacerbated Respiratory Disease - 2018 New England Journal of Medicine  Article 
 

2020 Brigham & Women's AERD Center Newsletter

2019 Brigham & Women's AERD Center Newsletter

2018 Brigham & Women's AERD Center Newsletter

2017 Brigham & Women's AERD Center Newletter

2016 Brigham & Women's AERD Center Newletter

2015 Scripps Patient Survey

Aspirin Desensitization

Aspirin Desensitization for Aspirin-Exacerbated Respiratory Disease in the Era of Biologics: Clinical Perspective - 2020 Article

Age as a Factor in Treatment of AERD: Relationship to Required Aspirin Maintenance Dose after Desensitization - 2020 Study

Complete Endoscopic Sinus Surgery Followed by Aspirin Desensitization is Associated With Decreased Overall Corticosteroid Use - 2020 Study

Major Complications of Aspirin Desensitization and Maintenance Therapy in AERD - 2020 Study

Analysis of Spirometry Measurements as Predictors of Aspirin Desensitization Outcomes - 2019 Study

The Time Course of Nasal Cytokine Secretion in Patients with Aspirin-Exacerbated Respiratory Disease (AERD) Undergoing Aspirin Desensitization - 2019 Study

Long Term Assessment of Aspirin Desensitization Shows Successful Bridging with Non-Aspirin Nonsteroidal Anti-Inflammatory Drugs for Procedures - 2019 Study

Sputum Biomarkers During Aspirin Desensitization in Nonsteroidal Anti-inflammatory Drugs Exacerbated Respiratory Disease - 2019 Study

Unique Effect of Aspirin Therapy on Biomarkers in Aspirin-Exacerbated Respiratory Disease: A Prospective Trial - 2019 Study

Aspirin Desensitization: Faster Protocols for Busy Patients - 2019 Article

Objective and Subjective Sinonasal and Pulmonary Outcomes in Aspirin Desensitization Therapy - 2019 Study

A One-Day, 90-Minute Aspirin Challenge and Desensitization Protocol in Aspirin-Exacerbated Respiratory Disease - 2018 Study

Aspirin Desensitization in Aspirin-Exacerbated Respiratory Disease: New Insights Into the Molecular Mechanisms - 2018 Study

Alcohol-Induced Respiratory Symptoms Improve After Aspirin Desensitization in Patients with AERD - 2018 Study

Long-term Clinical Outcomes of Aspirin Desensitization With Continuous Daily Aspirin Therapy in AERD - 2018 Study

Long-Term Follow-Up of Patients with Aspirin-Exacerbated Respiratory Disease Status Post-Desensitization - 2018 Study

 

Factors Correlated with Repeated Aspirin Dosing During Desensitization - 2018 Study

Outcomes after Complete Endoscopic Sinus Surgery and Aspirin Desensitization in AERD - 2018 Study

Safetey and Outcomes of Aspirin Desensitization - 2018 Study

Frequency & Severity of Reactions During Desensitization - 2017 Study

Nasal Ketorolac Challenge for AERD Diagnosis - 2017 Study

Use of a Composite Symptom Score During Challenge in Patients with Suspected Aspirin-Exacerbated Respiratory Disease - 2017 Study

The Role of Aspirin Desensitization in the Management of AERD - 2017 Review

Predictive Factors of Reaction Severity During Aspirin Desensitization - 2016 Study

A Survey of Aspirin Desensitization Practices Among Allergists and Fellows in Training in the United States - 2016 Letter

Alternative Aspirin Desensitization Protocol - 2015 Article

Aspirin Desensitization in AERD: Consideration of a New Oral Challenge Protocol - 2015 Editorial

Aspirin Desensitization for patients with AERD: A Randomized Double-Blind Placebo-Controlled Trial - 2015 Study

Evidence-Based Approach to Aspirin Desensitization in Aspirin-Exacerbated Respiratory Disease - 2014 Article

Aspirin Desensitization in Patients with Aspirin-Induced and Aspirin-Tolerant Asthma: A Double-Blind Study - 2014 Study

The Clinical Dilemma of "Silent Desensitization" in AERD - 2013 Study

Sinonasal Outcome Under Aspirin Desensitization Following Functional Endoscopic Sinus Surgery in Patients with Aspirin Triad - 2013 Study

Rational Approach to Dosing During Oral Challenge & Desnsitization - 2009 Study

An Economic Analysis of Aspirin Desensitization - 2008 Study

650 Versus 1300mg Aspirin Daily for AERD Treatment - 2007 Study

Predicting Severity of Reactions During Aspirin Desensitization - 2007 Study

Characterization of Ocular Reactions During Aspirin Challenge - 2005 Study

Long Term Treatment With Aspirin in AERD/Samter's Triad Patients - 2003 Study

Aspirin Desensitization in AERD: Clinical Manifestations and Characterization of the Refractory Period - 1982 Study

Biologic Medications

Dupilumab as Add-on Therapy for Chronic Rhinosinusitis With Nasal Polyposis in Aspirin Exacerbated Respiratory Disease - 2020 Study

Decreased Nasal Polyp Eosinophils but Increased Mast Cells in a Patient with Aspirin Exacerbated Respiratory Disease Treated with Reslizumab - 2020 Study

Mepolizumab Does Not Prevent All Aspirin Induced Reactions in Patients with Aspirin Exacerbated Respiratory Disease: A Case Series - 2020 Study

Aspirin Desensitization vs Biologics for Patients with Aspirin-Exacerbated Respiratory Disease - 2020 Article

 

A Multicenter Approach to Evaluate Omalizumab Effectiveness in Samter’s Triad- 2020 Study

Omalizumab for Aspirin-Hypersensitivity and Leukotriene Overproduction in Aspirin-Exacerbated Respiratory Disease: A Randomized Trial - 2020 Study

Dupilumab improves Nasal Polyp Burden and Asthma Control in Patients with CRSwNP and AERD- 2019 Study

Biologics in Chronic Rhinosinusitis with Nasal Polyposis - 2019 Study

Poor Control of Asthma Symptoms with Interleukin-5 Inhibitors in Four Patients with Aspirin Exacerbated Respiratory Disease - 2019 Study

Omalizumab Treatment in Samter's Triad: Case Series and Review of the Literature - 2019 Study

Aspirin Desensitization or Biologics for AERD? - 2019 Article

Effect of Omalizumab on Outcomes in Patients with Aspirin-Exacerbated Respiratory Disease - 2019 Study

AERD: Perspective of the Use of Licensed Monoclonals for Treatment Based on Their Phenotypes - 2019 Study

Omalizumab Can Inhibit Respiratory Reaction During Aspirin Desensitization - 2018 Study

A Pragmatic Analysis of Mepolizumab in Patients with Aspirin-Exacerbated Respiratory Disease - 2018 Study

Reduced Need for Sinus Surgery with Nucala - 2017 Study

Biologic Medications for Nasal Polyps - 2017 Review

Omalizumab (Xolair) in the Treatment of AERD - 2015 Letter

Effects of Omalizumab in Cases of Samter’s Syndrome - 2013 Article

Leukotriene Modifiers

AERD Associated Nasal Polyposis: Efficacy of Postoperative Antileukotriene Therapy in Comparison with Aspirin Desensitization. A Retrospective Study - 2020 Study

Effect of Zileuton Treatment on Sinonasal Quality of Life in Patients with Aspirin-Exacerbated Respiratory Disease - 2019 Study

The Effect of Antileukotrienes on the Results of Postoperative Treatment of Paranasal Sinuses in Patients with Non-Steroidal Anti-Inflammatory Drug-Exacerbated Respiratory Disease - 2019 Study

Efficacy of Zileuton in Patients with Asthma and History of Aspirin Sensitivity - 2017 Study

Improvement of Aspirin-Intolerant Asthma by Montelukast, a Leukotriene Antagonist - 2002 Study

The Effect of Leukotriene Modifier Drugs on Aspirin-Induced Asthma and Rhinitis Reactions - 2002 Study

Treatment of Aspirin-Intolerant Asthma with Anti-Leukotrienes - 2000 Study

Benefits from Adding Zileuton (Zyflo) to Conventional Therapy in AERD Patients - 1998 Study

 

Surgery & Other Treatments

 

Appropriate Extent of Surgery for Aspirin Exacerbated Respiratory Disease - 2020 Study

Endoscopic Sinus Surgery Improves Aspirin Treatment Response in Aspirin-Exacerbated Respiratory Disease Patients - 2019 Study

Sinus Surgery Effects on Diagnosis and Management of Patients with AERD - 2019 Article

Efficacy of Hypertonic (2.3%) Sea Water in Patients with AERD Following Endoscopic Sinus Surgery. - 2019 Study

Nasal Sinus Surgery Improves Lower Airway Reactivity during Aspirin Desensitization for AERD - 2019 Study

Is Topical High‐Volume Budesonide Sinus Irrigation Safe? - 2017 Review

Outcomes of Complete Versus Targeted Approaches to Endoscopic Sinus Surgery - 2015 Study

Safety and Effectiveness of Rinsing with Budesonide - 2014 Review

Revision Rates After Endoscopic Sinus Surgery: A Recurrence Analysis - 2011 Study

Canine Fossa Trephine is a Beneficial Procedure in Patients with Samter’s Triad - 2011 Study

Pilot Study of Budesonide Inhalant Suspension Irrigations for Chronic Eosinophilic Sinusitis - 2009 Study

The Effect of Nasally Administered Budesonide Respules on Adrenal Cortex Function in Patients With Chronic Rhinosinusitis - 2009 Study

 

Diet & Lifestyle

Possible Contribution of Decreased Phytoprostanes to Diet Induced Improvements in AERD - 2018 Letter to Editor

Can Diet Modification Be an Effective Treatment in AERD? - 2018 Article

Dietary Fatty Acid Modification for the Treatment of AERD - 2017 Study

Brigham & Women's Omega Fatty Acid Diet Guidelines

Quitting Smoking as a Risk Factor for Developing AERD - 2017 Study

Activation of Basophils and Eosinophils By EtOH in Alcohol - 2017 Study

Low Salicylate Diet - 2015 Study

Alcohol-Induced Respiratory Symptoms Are Common in Patients With AERD - 2014 Study

Alcohol & Polyphenols - 2014 Letter

Smoking, Environmental Tobacco Smoke, and AERD - 2012 Study

Sodium Salicylate and Aspirin Disease - 1980 Study

Safety of Specific Pain Relievers

Safety Risks for Patients with AERD After Acute Exposure to Selective NSAIDs and COX-2 Inhibitors  - 2014 Study

Safety of Etoricoxib, a Specific Cyclooxygenase-2 Inhibitor, in Asthmatic Patients with AERD - 2006 Study

Safety of Celecoxib (Celebrex) in AERD Patients - 2002 Study

Reactions to Tylenol -1995 Study

Salsalate Cross-Sensitivity in Aspirin-Sensitive Patients with Asthma - 1990 Study

 

 

 

Other AERD Research

AERD: Quo Vadis? - 2020 Editorial

Macrophages and Acylcarnitines; New Players in Aspirin-Exacerbated Respiratory Disease? - 2020 Article

Inflammatory Macrophage Memory in NSAID Exacerbated Respiratory Disease - 2020 Study

Differences in Men and Women Suffering from CRSwNP and AERD in Quality of Life - 2020 Study

Local Immunoglobulin Production in Nasal Tissues: A Key to Pathogenesis in CRSwNP and AERD - 2020 Study

Aural Polyps in Aspirin-Exacerbated Respiratory Disease - 2020 Study

The Role of Mast Cells in Aspirin-Exacerbated Respiratory Disease (AERD) Pathogenesis: Implications for Future Therapeutics - 2020 Review Article

Hypersensitivity to Dipyrone in Aspirin-Exacerbated Respiratory Disease Patients is Associated with Urticaria - 2020 Study

Chronic Rhinosinusitis With Nasal Polyps In Patients With Aspirin Sensitivity - Mycophenolate Mofetil as an Effective Steroid-Sparing Agent - 2020 Study

Elevated Urine Leukotriene E4 Is Associated With Worse Objective Markers in Nasal Polyposis Patients - 2020 Study

Lipid Mediated Innate Lymphoid Cell Recruitment and Activation in AERD - 2020 Study

Olfactory Outcomes in the Management of Aspirin Exacerbated Respiratory Disease Related Chronic Rhinosinusitis - 2020 Study

Is Otitis Media with Effusion Associated with Samter's Triad a New Nosological Entity? - 2020 Study

Leukotriene-Associated Rash in Aspirin-Exacerbated Respiratory Disease - 2020 Study

A Comparison of Sphenoid Sinus Osteoneogenesis in Aspirin-Exacerbated Respiratory Disease - 2020 Study

Does IgE Have a Role in Aspirin-Exacerbated Respiratory Disease?- 2020 Study

Inflammatory Macrophage Memory in NSAID-Exacerbated Respiratory Disease- 2020 Study

Hypersensitivity to Dipyrone in Aspirin-Exacerbated Respiratory Disease Patients is Associated with Urticaria- 2020 Study

Aspirin Exacerbated Respiratory Disease: Longitudinal Assessment of a Large Cohort and Implications of Diagnostic Delay - 2020 Study

Associations between the Quality of Life and Nasal Polyp Size in Patients Suffering from Chronic Rhinosinusitis without Nasal Polyps, with Nasal Polyps or AERD - 2020 Study

IL-5Rα Marks Nasal Polyp IgG4 and IgE-Expressing Cells in Aspirin-Exacerbated Respiratory Disease - 2020 Study

Aspirin-Exacerbated Respiratory Disease With Allergic Fungal Rhinosinusitis: A Case Series of Overlapping Sinonasal Endotypes - 2020 Study

A Genetic Variant Near TSLP is Associated with Chronic Rhinosinusitis with Nasal Polyps and AERD in Japanese Populations - 2019 Study

Expression of COX-1, COX-2, 5-LOX and CysLT2 in Nasal Polyps and Bronchial Tissue of Patients with AERD - 2019 Study

Subphenotypes of NSAID-Exacerbated Respiratory Disease Identified by Latent Class Analysis - 2019 Study

Treatment Practices for Aspirin-Exacerbated Respiratory Disease: Analysis of a National Insurance Claims Database - 2019 Study

Aspirin Sensitivity: Lessons in the Regulation (and Dysregulation) of Mast Cell Function - 2019 Article

A graduated Approach to Management of Chronic Rhinosinusitis in AERD in the Era of Precision Medicine - 2019 Article

Perimenstrual Asthma in Aspirin-Exacerbated Respiratory Disease - 2019 Study

Suppression of Aspirin Mediated Eosinophil Activation by Prostaglandin E2: Relevance to Aspirin/NSAID Hypersensitivity - 2019 Study

Prostaglandin E2 in NSAID-Exacerbated Respiratory Disease: Protection Against Cysteinyl Leukotrienes and Group 2 Innate Lymphoid Cells - 2019 Study

Longitudinal Progression of Aspirin-Exacerbated Respiratory Disease: Analysis of a National Insurance Claims Database - 2019 Study

Central Compartment Involvement in Aspirin-Exacerbated Respiratory Disease: The Role of Allergy and Previous Sinus Surgery - 2019 Study

Nasal provocation with Increased ASA Dose: Improved N‑ERD Detection Rate in Chronic Rhinosinusitis Patients - 2019 Study

Do NERDy Eosinophils Accelerate Nasal Polyp Growth? - 2019 Study

IL-5Rα Marks Nasal Polyp IgG4 and IgE-Secreting Cells in Aspirin-Exacerbated Respiratory Disease- 2019 Study

Aspirin-Exacerbated Respiratory Disease: A Syndrome of Mast Cell-Mediated PgD2- 2019 Article

Cysteinyl Leukotriene Receptor 2 Drives IL-33-Mediated Aspirin Sensitivity Through A Platelet Dependent Mechanism - 2019 Study

IL-4/IFN-γ Inflammatory Cytokine Profile Induces a Deficient Regulation of the IL-1β/IL-1RI/EP2/COX-2 Pathway in Nasal Mucosa - 2019 Study

Which Factors Associated With Activated Eosinophils Contribute to the Pathogenesis of Aspirin-Exacerbated Respiratory Disease? - 2019 Article

Aspirin Exacerbated Respiratory Disease: Epidemiology, Pathophysiology, and Management - 2019 Review

COX-1 Mediates IL-33–Induced Extracellular Signal-Regulated Kinase Activation in Mast Cells: Implications for Aspirin Sensitivity - 2019 Study

Surfactant Protein D Alleviates Eosinophil-Mediated Airway Inflammation and Remodeling in Patients with AERD - 2019 Study

Plasma Tryptase Elevation During Aspirin-Induced Reactions in Aspirin Exacerbated Respiratory Disease - 2019 Study

Nasal Polypectomy is Associated with Decreased Aspirin Sensitivity and Related Eicosanoid Changes in AERD Patients - 2019 Study

Aspirin-Exacerbated Respiratory Disease: Association of Sinus and Asthma Morbidity - 2019 Study

Staphylococcus Aureus Induces IL-33, TSLP, and Muc5AC Production by AERD Nasal Epithelium - 2019 Study

Nasal Challenge with Ketorolac: Utility and Safety in Clinical Practice - 2019 Study

Sex Differences in Prostaglandin E2-Dependent Homeostasis in Aspirin-Exacerbated Respiratory Disease - 2019 Study

Computed Tomography Findings in Patients with Samter’s Triad: an Observational Study - 2019 Study

Preoperative Sinonasal Symptom Scores Predict Post-Surgery, Post-Aspirin Desensitization Disease Status in AERD - 2019 Study

Role of Periostin in Brazilian Patients with Aspirin Exacerbated Respiratory Disease - 2019 Study

Associations Between TMEM196 Polymorphisms and NSAID Exacerbated Respiratory Disease in Asthma - 2019 Study

IL-5Rα Marks Nasal Polyp IgG4 and IgE Secreting Cells in Aspirin-Exacerbated Respiratory Disease - 2019 Study

Cysteinyl Leukotriene Receptor 2 Drives Lung Immunopathology Through a Platelet and High Mobility Box 1-Dependent Mechanism - 2019 Study

Heterogeneity of NSAID-Exacerbated Respiratory Disease - Has the Time Come for Subphenotyping? - 2019 Article

A trial of Type 12 Purinergic (P2Y12) Receptor Inhibition with Prasugrel Identifies a Potentially Distinct Endotype of Patients with AERD - 2019 Study

Clinical Updates in Aspirin-Exacerbated Respiratory Disease - 2019 Review

Accidental Ingestion of Aspirin and Nonsteroidal Anti-Inflammatory Drugs is Common in Patients with AERD - 2019 Study

Sinus Surgery is Associated with a Decrease in Aspirin-Induced Reaction Severity in AERD Patients - 2018 Study

Hearing Loss and Middle Ear Symptoms in Aspirin-Exacerbated Respiratory Disease - 2018 Study

Pathogenesis of NSAID-Induced Reactions in Aspirin-Exacerbated Respiratory Disease - 2018 Review

Diagnosis and Management of NSAID‐Exacerbated Respiratory Disease (N‐ERD) - 2018 EAACI Position Paper

Prostaglandin E2 Decrease in Induced Sputum of Hypersensitive Asthmatics During Oral Challenge with Aspirin - 2018 Study

Cortactin Expression in Nasal Polyps of Aspirin-Exacerbated Respiratory Disease (AERD) Patients - 2018 Study

The Utility of Biomarkers in Diagnosis of Aspirin Exacerbated Respiratory Disease - 2018 Study

Pathogenesis of NSAID-induced Reactions in Aspirin-Exacerbated Respiratory Disease - 2018 Review Article

A Retrospective Analysis of Esophageal Eosinophilia in Patients with Aspirin ExacerbatedRespiratory Disease - 2018 Study

MS4A2-rs573790 Is Associated With Aspirin-Exacerbated Respiratory Disease: Replicative Study Using a Candidate Gene Strategy - 2018 Study

Aspirin-Exacerbated Respiratory Disease - 2018 Article

Epithelial Folliculin Enhances Airway Inflammation in Aspirin‐Exacerbated Respiratory Disease - 2018 Study

COX-1 Mediates IL-33-Induced Extracellular Signal Regulated Kinase Activation in Mast Cells; Implications for Aspirin Sensitivity - 2018 Study

Depression Symptoms and Quality of Life Among Individuals with AERD - 2018 Study

Endocannabinoid Receptor CB2R is Significantly Expressed in AERD: A Pilot Study - 2018 Study

A trial of P2Y12 Receptor Inhibition with Prasugrel Identifies a Potentially Distinct Endotype of Patients with AERD - 2018 Study

 

Nasal Polyp IgE and IgG4 Levels are Elevated in AERD Patients - 2018 Study

Role of Group 2 Innate Lymphocytes in AERD Pathogenesis - 2018 Article

Frequency of Anti-inflammatory Related Cutaneous Manifestation in Patients with AERD - 2018 Study

Association of AERD with Airway Mycosis - 2018 Study

Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss Vasculitis) Presenting as Samter's Triad - 2018 Article

Clinical Characteristics of Patients with Chronic Rhinosinusitis with Nasal Polyps, Asthma, and Aspirin-Exacerbated Respiratory Disease - 2017 Study

Update on Aspirin-Exacerbated Respiratory Disease - 2017 Article

Potential Biomarkers for AERD Diagnosis - 2017 Study

Automated Identification of an Aspirin-Exacerbated Respiratory Disease Cohort - 2017 Study

Aspirin-Exacerbated Respiratory Disease: Mediators and Mechanisms of a Clinical Disease - 2017 Article

Eosinophils and Mast Cells in Aspirin Exacerbated Respiratory Disease - 2016 Review

Genetic and Epigenetic Components of Aspirin Exacerbated Respiratory Disease - 2016 Study

Coronary Artery Vasospasm in AERD Patients - 2016 Study

AERD Prevalence, Diagnosis, Treatment, and Future Considerations - 2016 Review

Thymic Stromal Lymphopoietin Controls Prostaglandin D2 Generation in Patients with AERD - 2016 Study

Aspirin-Exacerbated Respiratory Disease -- New Prime Suspects - 2016 Article

Reduced Nasal Brain Derived Neurotrophic Factor in Aspirin Exacerbated Respiratory Disease - 2016 Study

 

Survey-Defined Patient Experiences With Aspirin-Exacerbated Respiratory Disease - 2015 Study

Low Dose Aspirin Tolerance Does Not Preclude AERD - 2015 Letter

Low Dose Aspirin Use Delays AERD Diagnosis - 2015 Study

Prevalence of Aspirin-Exacerbated Respiratory Disease Among Asthmatics - 2015 Study

Prostaglandin D2: A Dominant Mediator of AERD - 2015 Study

Platelets in Patients with Aspirin-Exacerbated Respiratory Disease - 2015 Review

How Patient Experiences Should Change Our Approach to Treating Patients with AERD - 2015 Editorial

Elevated Total Serum IgE in Nonatopic Patients with - AERD - 2014 Study

Otologic Manifestation of Samter Triad - 2014 Case Study

AERD (Samter's Triad) Subtypes - 2014 Study

Prominent Role of IFN-g in Patients with AERD - 2013 Study

Presenation of AERD (Samter's Triad) in a 13 Year Old - 2013 Case Report

Eicosanoid Imbalance Correlates in Vitro with the Pattern of Clinical Symptoms of Samter´s triad - 2012 Study

Samter’s Triad and Eicosanoid Imbalance in Children with Recurrent Nasal Polyps - 2012 Article

Aspirin Sensitivity and Chronic Rhinosinusitis with Polyps: A Fatal Combination - 2012 Article

Expression of Melatonin in AERD/Samter's Triad Patients - 2011 Study

Predicting Outcomes of Oral Aspirin Challenges in Patients with Asthma, Nasal Polyps, and Chronic Sinusitis - 2008 Study

What Do We Know About the Genetics of Aspirin Intolerance? - 2008 Study

Otologic Manifestations of AERD (Samter's Triad) - 2007 Study

Aspirin Sensitivity and Severity of Asthma: Evidence for Irreversible Airway Obstruction in Patients with Severe or Difficult-to-Treat Asthma - 2005 Study

Natural History of Aspirin Induced Asthma - 2000 Study

Clinical Features and Diagnosis of Aspirin Induced Asthma - 2000 Study

Amalgam Allergy Associated with AERD Reactions - 1999 Case Study

Tryptase and Histamine Release During Aspirin-Induced Respiratory Reactions - 1991 Study

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