Research Library

Welcome to The AERD Research Library

Browse this collection of publications and research related to AERD (Samter's Triad). Be sure to check for updates - we add new materials frequently.

General Info & News

The Burden of NSAID Exacerbated Respiratory Disease from the Patient’s Perspective – A Qualitative Analysis of Posts from the Samter’s Society

Aspirin-Exacerbated Respiratory Disease - 2018 New England Journal of Medicine  Article 

2019 Brigham & Women's AERD Center Newsletter

2018 Brigham & Women's AERD Center Newsletter

2017 Brigham & Women's AERD Center Newletter

2016 Brigham & Women's AERD Center Newletter

2015 Scripps Patient Survey

Aspirin Desensitization

Complete Endoscopic Sinus Surgery Followed by Aspirin Desensitization is Associated With Decreased Overall Corticosteroid Use - 2020 Study

Analysis of Spirometry Measurements as Predictors of Aspirin Desensitization Outcomes - 2019 Study

The Time Course of Nasal Cytokine Secretion in Patients with Aspirin-Exacerbated Respiratory Disease (AERD) Undergoing Aspirin Desensitization - 2019 Study

Long Term Assessment of Aspirin Desensitization Shows Successful Bridging with Non-Aspirin Nonsteroidal Anti-Inflammatory Drugs for Procedures - 2019 Study

Sputum Biomarkers During Aspirin Desensitization in Nonsteroidal Anti-inflammatory Drugs Exacerbated Respiratory Disease - 2019 Study

Unique Effect of Aspirin Therapy on Biomarkers in Aspirin-Exacerbated Respiratory Disease: A Prospective Trial - 2019 Study

Aspirin Desensitization: Faster Protocols for Busy Patients - 2019 Article

Objective and Subjective Sinonasal and Pulmonary Outcomes in Aspirin Desensitization Therapy - 2019 Study

A One-Day, 90-Minute Aspirin Challenge and Desensitization Protocol in Aspirin-Exacerbated Respiratory Disease - 2018 Study

Aspirin Desensitization in Aspirin-Exacerbated Respiratory Disease: New Insights Into the Molecular Mechanisms - 2018 Study

Alcohol-Induced Respiratory Symptoms Improve After Aspirin Desensitization in Patients with AERD - 2018 Study

Long-term Clinical Outcomes of Aspirin Desensitization With Continuous Daily Aspirin Therapy in AERD - 2018 Study

Long-Term Follow-Up of Patients with Aspirin-Exacerbated Respiratory Disease Status Post-Desensitization - 2018 Study


Factors Correlated with Repeated Aspirin Dosing During Desensitization - 2018 Study

Outcomes after Complete Endoscopic Sinus Surgery and Aspirin Desensitization in AERD - 2018 Study

Safetey and Outcomes of Aspirin Desensitization - 2018 Study

Frequency & Severity of Reactions During Desensitization - 2017 Study

Nasal Ketorolac Challenge for AERD Diagnosis - 2017 Study

Use of a Composite Symptom Score During Challenge in Patients with Suspected Aspirin-Exacerbated Respiratory Disease - 2017 Study

The Role of Aspirin Desensitization in the Management of AERD - 2017 Review

Predictive Factors of Reaction Severity During Aspirin Desensitization - 2016 Study

A Survey of Aspirin Desensitization Practices Among Allergists and Fellows in Training in the United States - 2016 Letter

Alternative Aspirin Desensitization Protocol - 2015 Article

Aspirin Desensitization in AERD: Consideration of a New Oral Challenge Protocol - 2015 Editorial

Aspirin Desensitization for patients with AERD: A Randomized Double-Blind Placebo-Controlled Trial - 2015 Study

Evidence-Based Approach to Aspirin Desensitization in Aspirin-Exacerbated Respiratory Disease - 2014 Article

Aspirin Desensitization in Patients with Aspirin-Induced and Aspirin-Tolerant Asthma: A Double-Blind Study - 2014 Study

The Clinical Dilemma of "Silent Desensitization" in AERD - 2013 Study

Sinonasal Outcome Under Aspirin Desensitization Following Functional Endoscopic Sinus Surgery in Patients with Aspirin Triad - 2013 Study

Rational Approach to Dosing During Oral Challenge & Desnsitization - 2009 Study

An Economic Analysis of Aspirin Desensitization - 2008 Study

650 Versus 1300mg Aspirin Daily for AERD Treatment - 2007 Study

Predicting Severity of Reactions During Aspirin Desensitization - 2007 Study

Characterization of Ocular Reactions During Aspirin Challenge - 2005 Study

Long Term Treatment With Aspirin in AERD/Samter's Triad Patients - 2003 Study

Aspirin Desensitization in AERD: Clinical Manifestations and Characterization of the Refractory Period - 1982 Study

Biologic Medications

Omalizumab for Aspirin-Hypersensitivity and Leukotriene Overproduction in Aspirin-Exacerbated Respiratory Disease: A Randomized Trial - 2020 Study

Biologics in Chronic Rhinosinusitis with Nasal Polyposis - 2019 Study

Poor Control of Asthma Symptoms with Interleukin-5 Inhibitors in Four Patients with Aspirin Exacerbated Respiratory Disease - 2019 Study

Omalizumab Treatment in Samter's Triad: Case Series and Review of the Literature - 2019 Study

Aspirin Desensitization or Biologics for AERD? - 2019 Article

Effect of Omalizumab on Outcomes in Patients with Aspirin-Exacerbated Respiratory Disease - 2019 Study

AERD: Perspective of the Use of Licensed Monoclonals for Treatment Based on Their Phenotypes - 2019 Study

Efficacy and Safety of Dupilumab in Patients with Chronic Rhinosinusitis with Nasal Polyps: Results from the Randomized Phase 3 Sinus-24 Study - 2019 Study

Omalizumab Can Inhibit Respiratory Reaction During Aspirin Desensitization - 2018 Study

A Pragmatic Analysis of Mepolizumab in Patients with Aspirin-Exacerbated Respiratory Disease - 2018 Study

Reduced Need for Sinus Surgery with Nucala - 2017 Study

Biologic Medications for Nasal Polyps - 2017 Review

Oral Steroid Sparing Effect of Benralizumab (Fasenra) in Severe Asthma - 2017 Study

Omalizumab (Xolair) in the Treatment of AERD - 2015 Letter

Omalizumab (Xolair) is Effective in Allergic and Nonallergic Patients with Nasal Polyps and Asthma - 2013 Study

Effects of Omalizumab in Cases of Samter’s Syndrome - 2013 Article

Mepolizumab (Nucala) as a Treatment Option for Severe Nasal Polyposis - 2011 Study

Leukotriene Modifiers

Effect of Zileuton Treatment on Sinonasal Quality of Life in Patients with Aspirin-Exacerbated Respiratory Disease - 2019 Study

The Effect of Antileukotrienes on the Results of Postoperative Treatment of Paranasal Sinuses in Patients with Non-Steroidal Anti-Inflammatory Drug-Exacerbated Respiratory Disease - 2019 Study

Efficacy of Zileuton in Patients with Asthma and History of Aspirin Sensitivity - 2017 Study

Improvement of Aspirin-Intolerant Asthma by Montelukast, a Leukotriene Antagonist - 2002 Study

The Effect of Leukotriene Modifier Drugs on Aspirin-Induced Asthma and Rhinitis Reactions - 2002 Study

Treatment of Aspirin-Intolerant Asthma with Anti-Leukotrienes - 2000 Study

Benefits from Adding Zileuton (Zyflo) to Conventional Therapy in AERD Patients - 1998 Study


Surgery & Other Treatments


Endoscopic Sinus Surgery Improves Aspirin Treatment Response in Aspirin-Exacerbated Respiratory Disease Patients - 2019 Study

Sinus Surgery Effects on Diagnosis and Management of Patients with AERD - 2019 Article

Efficacy of Hypertonic (2.3%) Sea Water in Patients with AERD Following Endoscopic Sinus Surgery. - 2019 Study

Nasal Sinus Surgery Improves Lower Airway Reactivity during Aspirin Desensitization for AERD - 2019 Study

Is Topical High‐Volume Budesonide Sinus Irrigation Safe? - 2017 Review

Outcomes of Complete Versus Targeted Approaches to Endoscopic Sinus Surgery - 2015 Study

Safety and Effectiveness of Rinsing with Budesonide - 2014 Review

Revision Rates After Endoscopic Sinus Surgery: A Recurrence Analysis - 2011 Study

Canine Fossa Trephine is a Beneficial Procedure in Patients with Samter’s Triad - 2011 Study

Pilot Study of Budesonide Inhalant Suspension Irrigations for Chronic Eosinophilic Sinusitis - 2009 Study

The Effect of Nasally Administered Budesonide Respules on Adrenal Cortex Function in Patients With Chronic Rhinosinusitis - 2009 Study


Diet & Lifestyle

Possible Contribution of Decreased Phytoprostanes to Diet Induced Improvements in AERD - 2018 Letter to Editor

Can Diet Modification Be an Effective Treatment in AERD? - 2018 Article

Dietary Fatty Acid Modification for the Treatment of AERD - 2017 Study

Brigham & Women's Omega Fatty Acid Diet Guidelines

Quitting Smoking as a Risk Factor for Developing AERD - 2017 Study

Activation of Basophils and Eosinophils By EtOH in Alcohol - 2017 Study

Low Salicylate Diet - 2015 Study

Alcohol-Induced Respiratory Symptoms Are Common in Patients With AERD - 2014 Study

Alcohol & Polyphenols - 2014 Letter

Smoking, Environmental Tobacco Smoke, and AERD - 2012 Study

Sodium Salicylate and Aspirin Disease - 1980 Study

Safety of Specific Pain Relievers

Safety Risks for Patients with AERD After Acute Exposure to Selective NSAIDs and COX-2 Inhibitors  - 2014 Study

Safety of Etoricoxib, a Specific Cyclooxygenase-2 Inhibitor, in Asthmatic Patients with AERD - 2006 Study

Safety of Celecoxib (Celebrex) in AERD Patients - 2002 Study

Reactions to Tylenol -1995 Study

Salsalate Cross-Sensitivity in Aspirin-Sensitive Patients with Asthma - 1990 Study




Other AERD Research

Leukotriene-Associated Rash in Aspirin-Exacerbated Respiratory Disease - 2020 Study

Does IgE Have a Role in Aspirin-Exacerbated Respiratory Disease?- 2020 Study

Inflammatory Macrophage Memory in NSAID-Exacerbated Respiratory Disease- 2020 Study

Hypersensitivity to Dipyrone in Aspirin-Exacerbated Respiratory Disease Patients is Associated with Urticaria- 2020 Study

Aspirin Exacerbated Respiratory Disease: Longitudinal Assessment of a Large Cohort and Implications of Diagnostic Delay - 2020 Study

Associations between the Quality of Life and Nasal Polyp Size in Patients Suffering from Chronic Rhinosinusitis without Nasal Polyps, with Nasal Polyps or AERD - 2020 Study

IL-5Rα Marks Nasal Polyp IgG4 and IgE-Expressing Cells in Aspirin-Exacerbated Respiratory Disease - 2020 Study

Aspirin-Exacerbated Respiratory Disease With Allergic Fungal Rhinosinusitis: A Case Series of Overlapping Sinonasal Endotypes - 2020 Study

A Genetic Variant Near TSLP is Associated with Chronic Rhinosinusitis with Nasal Polyps and AERD in Japanese Populations - 2019 Study

Expression of COX-1, COX-2, 5-LOX and CysLT2 in Nasal Polyps and Bronchial Tissue of Patients with AERD - 2019 Study

Subphenotypes of NSAID-Exacerbated Respiratory Disease Identified by Latent Class Analysis - 2019 Study

Treatment Practices for Aspirin-Exacerbated Respiratory Disease: Analysis of a National Insurance Claims Database - 2019 Study

Aspirin Sensitivity: Lessons in the Regulation (and Dysregulation) of Mast Cell Function - 2019 Article

A graduated Approach to Management of Chronic Rhinosinusitis in AERD in the Era of Precision Medicine - 2019 Article

Perimenstrual Asthma in Aspirin-Exacerbated Respiratory Disease - 2019 Study

Suppression of Aspirin Mediated Eosinophil Activation by Prostaglandin E2: Relevance to Aspirin/NSAID Hypersensitivity - 2019 Study

Prostaglandin E2 in NSAID-Exacerbated Respiratory Disease: Protection Against Cysteinyl Leukotrienes and Group 2 Innate Lymphoid Cells - 2019 Study

Longitudinal Progression of Aspirin-Exacerbated Respiratory Disease: Analysis of a National Insurance Claims Database - 2019 Study

Central Compartment Involvement in Aspirin-Exacerbated Respiratory Disease: The Role of Allergy and Previous Sinus Surgery - 2019 Study

Nasal provocation with Increased ASA Dose: Improved N‑ERD Detection Rate in Chronic Rhinosinusitis Patients - 2019 Study

Do NERDy Eosinophils Accelerate Nasal Polyp Growth? - 2019 Study

IL-5Rα Marks Nasal Polyp IgG4 and IgE-Secreting Cells in Aspirin-Exacerbated Respiratory Disease- 2019 Study

Aspirin-Exacerbated Respiratory Disease: A Syndrome of Mast Cell-Mediated PgD2- 2019 Article

Cysteinyl Leukotriene Receptor 2 Drives IL-33-Mediated Aspirin Sensitivity Through A Platelet Dependent Mechanism - 2019 Study

IL-4/IFN-γ Inflammatory Cytokine Profile Induces a Deficient Regulation of the IL-1β/IL-1RI/EP2/COX-2 Pathway in Nasal Mucosa - 2019 Study

Which Factors Associated With Activated Eosinophils Contribute to the Pathogenesis of Aspirin-Exacerbated Respiratory Disease? - 2019 Article

Aspirin Exacerbated Respiratory Disease: Epidemiology, Pathophysiology, and Management - 2019 Review

COX-1 Mediates IL-33–Induced Extracellular Signal-Regulated Kinase Activation in Mast Cells: Implications for Aspirin Sensitivity - 2019 Study

Surfactant Protein D Alleviates Eosinophil-Mediated Airway Inflammation and Remodeling in Patients with AERD - 2019 Study

Plasma Tryptase Elevation During Aspirin-Induced Reactions in Aspirin Exacerbated Respiratory Disease - 2019 Study

Nasal Polypectomy is Associated with Decreased Aspirin Sensitivity and Related Eicosanoid Changes in AERD Patients - 2019 Study

Aspirin-Exacerbated Respiratory Disease: Association of Sinus and Asthma Morbidity - 2019 Study

Staphylococcus Aureus Induces IL-33, TSLP, and Muc5AC Production by AERD Nasal Epithelium - 2019 Study

Nasal Challenge with Ketorolac: Utility and Safety in Clinical Practice - 2019 Study

Sex Differences in Prostaglandin E2-Dependent Homeostasis in Aspirin-Exacerbated Respiratory Disease - 2019 Study

Computed Tomography Findings in Patients with Samter’s Triad: an Observational Study - 2019 Study

Preoperative Sinonasal Symptom Scores Predict Post-Surgery, Post-Aspirin Desensitization Disease Status in AERD - 2019 Study

Role of Periostin in Brazilian Patients with Aspirin Exacerbated Respiratory Disease - 2019 Study

Associations Between TMEM196 Polymorphisms and NSAID Exacerbated Respiratory Disease in Asthma - 2019 Study

IL-5Rα Marks Nasal Polyp IgG4 and IgE Secreting Cells in Aspirin-Exacerbated Respiratory Disease - 2019 Study

Cysteinyl Leukotriene Receptor 2 Drives Lung Immunopathology Through a Platelet and High Mobility Box 1-Dependent Mechanism - 2019 Study

Heterogeneity of NSAID-Exacerbated Respiratory Disease - Has the Time Come for Subphenotyping? - 2019 Article

A trial of Type 12 Purinergic (P2Y12) Receptor Inhibition with Prasugrel Identifies a Potentially Distinct Endotype of Patients with AERD - 2019 Study

Clinical Updates in Aspirin-Exacerbated Respiratory Disease - 2019 Review

Accidental Ingestion of Aspirin and Nonsteroidal Anti-Inflammatory Drugs is Common in Patients with AERD - 2019 Study

Sinus Surgery is Associated with a Decrease in Aspirin-Induced Reaction Severity in AERD Patients - 2018 Study

Hearing Loss and Middle Ear Symptoms in Aspirin-Exacerbated Respiratory Disease - 2018 Study

Pathogenesis of NSAID-Induced Reactions in Aspirin-Exacerbated Respiratory Disease - 2018 Review

Diagnosis and Management of NSAID‐Exacerbated Respiratory Disease (N‐ERD) - 2018 EAACI Position Paper

Prostaglandin E2 Decrease in Induced Sputum of Hypersensitive Asthmatics During Oral Challenge with Aspirin - 2018 Study

Cortactin Expression in Nasal Polyps of Aspirin-Exacerbated Respiratory Disease (AERD) Patients - 2018 Study

The Utility of Biomarkers in Diagnosis of Aspirin Exacerbated Respiratory Disease - 2018 Study

Pathogenesis of NSAID-induced Reactions in Aspirin-Exacerbated Respiratory Disease - 2018 Review Article

A Retrospective Analysis of Esophageal Eosinophilia in Patients with Aspirin ExacerbatedRespiratory Disease - 2018 Study

MS4A2-rs573790 Is Associated With Aspirin-Exacerbated Respiratory Disease: Replicative Study Using a Candidate Gene Strategy - 2018 Study

Aspirin-Exacerbated Respiratory Disease - 2018 Article

Epithelial Folliculin Enhances Airway Inflammation in Aspirin‐Exacerbated Respiratory Disease - 2018 Study

COX-1 Mediates IL-33-Induced Extracellular Signal Regulated Kinase Activation in Mast Cells; Implications for Aspirin Sensitivity - 2018 Study

Depression Symptoms and Quality of Life Among Individuals with AERD - 2018 Study

Endocannabinoid Receptor CB2R is Significantly Expressed in AERD: A Pilot Study - 2018 Study

A trial of P2Y12 Receptor Inhibition with Prasugrel Identifies a Potentially Distinct Endotype of Patients with AERD - 2018 Study


Nasal Polyp IgE and IgG4 Levels are Elevated in AERD Patients - 2018 Study

Role of Group 2 Innate Lymphocytes in AERD Pathogenesis - 2018 Article

Frequency of Anti-inflammatory Related Cutaneous Manifestation in Patients with AERD - 2018 Study

Association of AERD with Airway Mycosis - 2018 Study

Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss Vasculitis) Presenting as Samter's Triad - 2018 Article

Clinical Characteristics of Patients with Chronic Rhinosinusitis with Nasal Polyps, Asthma, and Aspirin-Exacerbated Respiratory Disease - 2017 Study

Update on Aspirin-Exacerbated Respiratory Disease - 2017 Article

Potential Biomarkers for AERD Diagnosis - 2017 Study

Automated Identification of an Aspirin-Exacerbated Respiratory Disease Cohort - 2017 Study

Aspirin-Exacerbated Respiratory Disease: Mediators and Mechanisms of a Clinical Disease - 2017 Article

Eosinophils and Mast Cells in Aspirin Exacerbated Respiratory Disease - 2016 Review

Genetic and Epigenetic Components of Aspirin Exacerbated Respiratory Disease - 2016 Study

Coronary Artery Vasospasm in AERD Patients - 2016 Study

AERD Prevalence, Diagnosis, Treatment, and Future Considerations - 2016 Review

Thymic Stromal Lymphopoietin Controls Prostaglandin D2 Generation in Patients with AERD - 2016 Study

Aspirin-Exacerbated Respiratory Disease -- New Prime Suspects - 2016 Article

Reduced Nasal Brain Derived Neurotrophic Factor in Aspirin Exacerbated Respiratory Disease - 2016 Study


Survey-Defined Patient Experiences With Aspirin-Exacerbated Respiratory Disease - 2015 Study

Low Dose Aspirin Tolerance Does Not Preclude AERD - 2015 Letter

Low Dose Aspirin Use Delays AERD Diagnosis - 2015 Study

Prevalence of Aspirin-Exacerbated Respiratory Disease Among Asthmatics - 2015 Study

Prostaglandin D2: A Dominant Mediator of AERD - 2015 Study

Platelets in Patients with Aspirin-Exacerbated Respiratory Disease - 2015 Review

How Patient Experiences Should Change Our Approach to Treating Patients with AERD - 2015 Editorial

Elevated Total Serum IgE in Nonatopic Patients with - AERD - 2014 Study

Otologic Manifestation of Samter Triad - 2014 Case Study

AERD (Samter's Triad) Subtypes - 2014 Study

Prominent Role of IFN-g in Patients with AERD - 2013 Study

Presenation of AERD (Samter's Triad) in a 13 Year Old - 2013 Case Report

Eicosanoid Imbalance Correlates in Vitro with the Pattern of Clinical Symptoms of Samter´s triad - 2012 Study

Samter’s Triad and Eicosanoid Imbalance in Children with Recurrent Nasal Polyps - 2012 Article

Aspirin Sensitivity and Chronic Rhinosinusitis with Polyps: A Fatal Combination - 2012 Article

Expression of Melatonin in AERD/Samter's Triad Patients - 2011 Study

Predicting Outcomes of Oral Aspirin Challenges in Patients with Asthma, Nasal Polyps, and Chronic Sinusitis - 2008 Study

What Do We Know About the Genetics of Aspirin Intolerance? - 2008 Study

Otologic Manifestations of AERD (Samter's Triad) - 2007 Study

Aspirin Sensitivity and Severity of Asthma: Evidence for Irreversible Airway Obstruction in Patients with Severe or Difficult-to-Treat Asthma - 2005 Study

Natural History of Aspirin Induced Asthma - 2000 Study

Clinical Features and Diagnosis of Aspirin Induced Asthma - 2000 Study

Amalgam Allergy Associated with AERD Reactions - 1999 Case Study

Tryptase and Histamine Release During Aspirin-Induced Respiratory Reactions - 1991 Study

Research Links

If you're interested in reading other studies, there are several journals that often publish research on Aspirin Exacerbated Respiratory Disease (AERD, Samter's Triad). 

The Journal of Allergy and Clinical Immunology

The Journal of Allergy and Clinical Immunology: In Practice

American Journal of Allergy and Rhinology

Annals of Allergy, Asthma, and Immunology

Allergology International

International Forum of Allergy & Rhinology

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